Top Applications in Human ES Cell and iPS Cell Research
As part of the Pluripotent Profiles series, ºÚÁÏ³Ô¹Ï has selected influential publications that have supported the following applications of human ES cells and iPS cells. View our lists of top five publications, and read the interviews to learn what some of these researchers have said about their work.
Key Applications
Toxicity Testing with Human iPS Cells
Jagtap S, Meganathan K, Gaspar J, Wagh V, Winkler J, Hescheler J and Sachinidis A (2011), , Br J Pharmacol. Vol. 162, pp. 1743-56.
Kleinstreuer NC, Smith AM, West PR, Conard KR, Fontaine BR, Weir-Hauptman AM, Palmer JA, Knudsen TB, Dix DJ, Donley ELR and Cezar GG (2011), , Toxicology and Applied Pharmacology., November, 2011. Vol. 257(1), pp. 111-121.
Liang P, Lan F, Lee AS, Gong T, Sanchez-Freire V, Wang Y, Diecke S, Sallam K, Knowles JW, Wang PJ, Nguyen PK, Bers DM, Robbins RC and Wu JC (2013), Circulation., April, 2013. Vol. 127(16), pp. 1677-1691.
Liu J, Sun N, Bruce MA, Wu JC and Butte MJ (2012), , PLoS ONE., May, 2012. Vol. 7(5), pp. e37559.
Mehta A, Chung YY, Ng A, Iskandar F, Atan S, Wei H, Dusting G, Sun W, Wong P and Shim W (2011), , Cardiovascular Research., September, 2011. Vol. 91(4), pp. 577-586.
Kleinstreuer NC, Smith AM, West PR, Conard KR, Fontaine BR, Weir-Hauptman AM, Palmer JA, Knudsen TB, Dix DJ, Donley ELR and Cezar GG (2011), , Toxicology and Applied Pharmacology., November, 2011. Vol. 257(1), pp. 111-121.
Liang P, Lan F, Lee AS, Gong T, Sanchez-Freire V, Wang Y, Diecke S, Sallam K, Knowles JW, Wang PJ, Nguyen PK, Bers DM, Robbins RC and Wu JC (2013), Circulation., April, 2013. Vol. 127(16), pp. 1677-1691.
Liu J, Sun N, Bruce MA, Wu JC and Butte MJ (2012), , PLoS ONE., May, 2012. Vol. 7(5), pp. e37559.
Mehta A, Chung YY, Ng A, Iskandar F, Atan S, Wei H, Dusting G, Sun W, Wong P and Shim W (2011), , Cardiovascular Research., September, 2011. Vol. 91(4), pp. 577-586.
Differentiating to Hematopoietic Cells
Brown ME, Rondon E, Rajesh D, Mack A, Lewis R, Feng X, Zitur LJ, Learish RD and Nuwaysir EF (2010), , PLoS One. Vol. 5, pp. e11373.
Carpenter L, Malladi R, Yang C-T, French A, Pilkington KJ, Forsey RW, Sloane-Stanley J, Silk KM, Davies TJ, Fairchild PJ, Enver T and Watt SM (2011), , Blood., April, 2011. Vol. 117(15), pp. 4008-4011.
Dravid G, Zhu Y, Scholes J, Evseenko D and Crooks GM (2011), , Mol Ther. Vol. 19, pp. 768-81.
Niwa A, Heike T, Umeda K, Oshima K, Kato I, Sakai H, Suemori H, Nakahata T and Saito MK (2011), , PLoS One. Vol. 6, pp. e22261.
Salvagiotto G, Burton S, Daigh CA, Rajesh D, Slukvin II and Seay NJ (2011), , PLoS ONE., March, 2011. Vol. 6(3), pp. e17829.
Carpenter L, Malladi R, Yang C-T, French A, Pilkington KJ, Forsey RW, Sloane-Stanley J, Silk KM, Davies TJ, Fairchild PJ, Enver T and Watt SM (2011), , Blood., April, 2011. Vol. 117(15), pp. 4008-4011.
Dravid G, Zhu Y, Scholes J, Evseenko D and Crooks GM (2011), , Mol Ther. Vol. 19, pp. 768-81.
Niwa A, Heike T, Umeda K, Oshima K, Kato I, Sakai H, Suemori H, Nakahata T and Saito MK (2011), , PLoS One. Vol. 6, pp. e22261.
Salvagiotto G, Burton S, Daigh CA, Rajesh D, Slukvin II and Seay NJ (2011), , PLoS ONE., March, 2011. Vol. 6(3), pp. e17829.
Differentiating to Definitive Endoderm
Hannoun Z, Fletcher J, Greenhough S, Medine C, Samuel K, Sharma R, Pryde A, Black JR, Ross JA, Wilmut I, Iredale JP and Hay DC (2010), , Cell Reprogram. Vol. 12, pp. 133-40.
Jaramillo M and Banerjee I (2012), , Journal of Visualized Experiments., March, 2012. (61)
Miki T, Ring A and Gerlach J (2011), , Tissue Eng Part C Methods. Vol. 17, pp. 557-68.
Mou H, Zhao R, Sherwood R, Ahfeldt T, Lapey A, Wain J, Sicilian L, Izvolsky K, Lau FH, Musunuru K, Cowan C and Rajagopal J (2012), , Cell Stem Cell., April, 2012. Vol. 10(4), pp. 385-397.
Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF and Wells JM (2011), , Nature., February, 2011. Vol. 470(7332), pp. 105-109.
Jaramillo M and Banerjee I (2012), , Journal of Visualized Experiments., March, 2012. (61)
Miki T, Ring A and Gerlach J (2011), , Tissue Eng Part C Methods. Vol. 17, pp. 557-68.
Mou H, Zhao R, Sherwood R, Ahfeldt T, Lapey A, Wain J, Sicilian L, Izvolsky K, Lau FH, Musunuru K, Cowan C and Rajagopal J (2012), , Cell Stem Cell., April, 2012. Vol. 10(4), pp. 385-397.
Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF and Wells JM (2011), , Nature., February, 2011. Vol. 470(7332), pp. 105-109.
Scale-Up and Bioreactor Culture
Krawetz R, Taiani JT, Liu S, Meng G, Li X, Kallos MS and Rancourt DE (2010), , Tissue Engineering Part C: Methods., August, 2010. Vol. 16(4), pp. 573-582.
Oh SKW, Chen AK, Mok Y, Chen X, Lim U-M, Chin A, Choo ABH and Reuveny S (2009), , Stem Cell Research., May, 2009. Vol. 2(3), pp. 219-230.
Olmer R, Haase A, Merkert S, Cui W, Palecek J, Ran C, Kirschning A, Scheper T, Glage S, Miller K, Curnow EC, Hayes ES and Martin U (2010), , Stem Cell Res. Vol. 5, pp. 51-64.
Singh H, Mok P, Balakrishnan T, Rahmat SN and Zweigerdt R (2010), , Stem Cell Res. Vol. 4, pp. 165-79.
Zweigerdt R, Olmer R, Singh H, Haverich A and Martin U (2011), , Nature Protocols. Vol. 6(5), pp. 689-700.
Oh SKW, Chen AK, Mok Y, Chen X, Lim U-M, Chin A, Choo ABH and Reuveny S (2009), , Stem Cell Research., May, 2009. Vol. 2(3), pp. 219-230.
Olmer R, Haase A, Merkert S, Cui W, Palecek J, Ran C, Kirschning A, Scheper T, Glage S, Miller K, Curnow EC, Hayes ES and Martin U (2010), , Stem Cell Res. Vol. 5, pp. 51-64.
Singh H, Mok P, Balakrishnan T, Rahmat SN and Zweigerdt R (2010), , Stem Cell Res. Vol. 4, pp. 165-79.
Zweigerdt R, Olmer R, Singh H, Haverich A and Martin U (2011), , Nature Protocols. Vol. 6(5), pp. 689-700.
Differentiating to Cardiomyocytes
Elliott DA, Braam SR, Koutsis K, Ng ES, Jenny R, Lagerqvist EL, Biben C, Hatzistavrou T, Hirst CE, Yu QC, Skelton RJ, Ward-van Oostwaard D, Lim SM, Khammy O, Li X, Hawes SM, Davis RP, Goulburn AL, Passier R, Prall OW, Haynes JM, Pouton CW, Kaye DM, Mummery CL, Elefanty AG and Stanley EG (2011), , Nat Methods. Vol. 8, pp. 1037-40.
Hazeltine LB, Simmons CS, Salick MR, Lian X, Badur MG, Han W, Delgado SM, Wakatsuki T, Crone WC, Pruitt BL and Palecek SP (2012), , International Journal of Cell Biology. Vol. 2012, pp. 1-13.
Lian X, Hsiao C, Wilson G, Zhu K, Hazeltine LB, Azarin SM, Raval KK, Zhang J, Kamp TJ and Palecek SP (2012), , Proceedings of the National Academy of Sciences., July, 2012. Vol. 109(27), pp. 10759-10760.
Mehta A, Chung YY, Ng A, Iskandar F, Atan S, Wei H, Dusting G, Sun W, Wong P and Shim W (2011), , Cardiovascular Research., September, 2011. Vol. 91(4), pp. 577-586.
Zhang H, Zou B, Yu H, Moretti A, Wang X, Yan W, Babcock JJ, Bellin M, McManus OB, Tomaselli G, Nan F, Laugwitz K-L and Li M (2012), , Proceedings of the National Academy of Sciences., July, 2012. Vol. 109(29), pp. 11866-11871.
Hazeltine LB, Simmons CS, Salick MR, Lian X, Badur MG, Han W, Delgado SM, Wakatsuki T, Crone WC, Pruitt BL and Palecek SP (2012), , International Journal of Cell Biology. Vol. 2012, pp. 1-13.
Lian X, Hsiao C, Wilson G, Zhu K, Hazeltine LB, Azarin SM, Raval KK, Zhang J, Kamp TJ and Palecek SP (2012), , Proceedings of the National Academy of Sciences., July, 2012. Vol. 109(27), pp. 10759-10760.
Mehta A, Chung YY, Ng A, Iskandar F, Atan S, Wei H, Dusting G, Sun W, Wong P and Shim W (2011), , Cardiovascular Research., September, 2011. Vol. 91(4), pp. 577-586.
Zhang H, Zou B, Yu H, Moretti A, Wang X, Yan W, Babcock JJ, Bellin M, McManus OB, Tomaselli G, Nan F, Laugwitz K-L and Li M (2012), , Proceedings of the National Academy of Sciences., July, 2012. Vol. 109(29), pp. 11866-11871.
Most of the ground-breaking research profiled here was supported by ³¾°Õ±ð³§¸éâ„¢1, the most widely published cell culture medium for the feeder-free maintenance of ES cells and iPS cells. A highly specialized, serum-free and complete cell culture medium, ³¾°Õ±ð³§¸éâ„¢1 has been used in over 40 countries to successfully maintain hundreds of ES cell and iPS cell lines.
