"Blood Cells and the Bone Marrow" Featuring Dr. Dominique Bonnet
On this episode of the Stem Cell Podcast, Dr. Dominique Bonnet from the Francis Crick Institute discusses her research into why and how acute myeloid leukemia develops in the bone marrow.
Dr. Dominique Bonnet is the Group Leader of the Hematopoietic Stem Cell Laboratory at the Francis Crick Institute in London, UK. Her lab is interested in the extrinsic mechanisms that regulate hematopoietic stem cells, and how they can intervene in order to eradicate the leukemic stem cell.
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This Episode's Stem Cell Roundup:
- – A very compact CRISPR-Cas system has been identified in huge bacteriophages, which provides an addition to the genome editing toolbox.
- – Scientists have found that heart attacks can affect glucose tolerance by acting on hematopoietic progenitor-derived macrophages in distal adipose tissue.
- – Investigators have found that certain cell types form a niche to regulate hair follicular stem cells and promote goosebumps.
- – Combining a BMI1 inhibitor with approved PD1 blockade treatment successfully eliminated cancer stem cells in head and neck squamous cell carcinoma.
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