“Exploring Regulatory T Cells” Featuring Dr. Michael Rosenblum
On this episode of the Immunology Podcast, Dr. Michael Rosenblum talks about regulatory T cells in the skin and how they can be manipulated to fight autoimmune diseases and cancer.
Dr. Michael Rosenblum is a Professor of Dermatology at the University of California, San Francisco. His lab seeks to understand how immune responses are regulated in tissues and how this knowledge can be exploited for therapeutic benefit. They are currently investigating how regulatory T cells (Tregs) control immune responses in tissues, as well as their “alternative” functions. He talks about early-life inflammation and type 2 helper T cells in the skin, and how Tregs can be manipulated to target autoimmune diseases and cancer.
It was exciting to discuss with Dr. Rosenblum the therapeutic path forward for Tregs, particularly in the skin.
Dr. Jason Goldsmith, host
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This Episode's Immunology Roundup:
- – After viral brain infection, tissue-resident memory T cells triggered central nervous system inflammation, promoting autoimmune reactions in mice.
- – Anti-HIV-1 antibodies can maintain viral suppression and may accelerate viral reservoir decay.
- – Natural killer cell depletion enhanced T cell responses to a chimp adenoviral vectored hepatitis B virus.
- – Researchers found that interferon gamma signaling is crucial for proper engagement and killing of solid tumors by CAR T cells.
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