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The L243 antibody reacts with human HLA-DR, the major histocompatibility complex (MHC) class II receptor and a member of the immunoglobulin protein superfamily. HLA-DR is a heterodimeric transmembrane glycoprotein comprising a 36-kDa α subunit associated non-covalently with a 27-kDa β subunit and is expressed on the surface of antigen-presenting cells such as B cells, activated T cells, monocytes, macrophages and dendritic cells, activated natural killer (NK) cells, and progenitor cells. Together with the CD3/T cell receptor (TCR) complex and CD4 molecules, HLA-DR mediates a critical function in presenting peptides generated from hydrolysis of exogenous antigens by antigen-presenting cells to CD4+T (helper) cells, thereby either suppressing or inducing an immune response to the peptides. Thus, HLA-DR is involved in graft-versus-host disease and several autoimmune conditions. The L243 antibody binds an extracellular, conformational, and nonpolymorphic epitope on the α chain that is expressed only when the αβ heterodimer is correctly folded, and binding is not dependent on peptide loading of HLA-DR. Binding of the antibody blocks the association of HLA-DR with TCRs and reportedly exerts cytotoxic effects on human cells. The L243 antibody does not cross-react with HLA-DQ or HLA-DP.
Subtype
Primary Antibodies
Target Antigen
HLA-DR
Alternative Names
HLA-DRA, Major histocompatibility class II, Major histocompatibility class II DR alpha, MHC class II, MHC class II DR alpha, MGC117330, MLRW
Reactive Species
African Green Monkey, Baboon, Chimpanzee, Common Marmoset, Cotton-Topped Tamarin, Cynomolgus, Dog, Human, Pigtailed Macaque, Rhesus, Squirrel Monkey
Figure 1. Data for Anti-Human HLA-DR Antibody, Clone L243, APC
Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human HLA-DR Antibody, Clone L243, APC (filled histogram) or a mouse IgG2a, kappa APC isotype control antibody (solid line histogram). Viable lymphocytes were gated for analysis.
Figure 2. Data for Anti-Human HLA-DR Antibody, Clone L243, APC-Cy7
Flow cytometry analysis of human PBMCs labeled with Anti-Human HLA-DR Antibody, Clone L243, APC-Cyanine7 (filled histogram) or a mouse IgG2a, kappa APC-Cyanine7 isotype control antibody (solid line histogram). Viable lymphocytes were gated for analysis.
Figure 3. Data for Anti-Human HLA-DR Antibody, Clone L243, FITC
Flow cytometry analysis of human PBMCs labeled with Anti-Human HLA-DR Antibody, Clone L243, FITC (filled histogram) or a mouse IgG2a, kappa FITC isotype control antibody (solid line histogram). Viable lymphocytes were gated for analysis.
Figure 4. Data for Anti-Human HLA-DR Antibody, Clone L243, PE
Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human HLA-DR Antibody, Clone L243, PE (filled histogram) or a mouse IgG2a, kappa PE isotype control antibody (solid line histogram). Viable lymphocytes were gated for analysis.
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Mouse monoclonal IgG2b antibody against human, rhesus HLA-DR
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Anti-Human HLA-DR, Clone L243
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