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The RMEPCR1560 (1560) antibody reacts with the endothelial protein C receptor (EPCR or CD201), an ~25 kDa type I transmembrane glycoprotein expressed by endothelial cells, subsets of hematopoietic stem cells (HSCs) and dendritic cells, and several malignant cell lines. It is also found in a soluble form in plasma. EPCR exhibits homology with the MHC class 1/CD1 protein family. EPCR binds protein C and activated protein C, thus augmenting protein C activation by the thrombin-thrombomodulin complex and regulating blood coagulation and inflammation. EPCR protein expression has been detected on ~1.5% of mouse bone marrow cells. Purified EPCR+ cells are highly enriched for HSC activity, as evidenced by high in vivo repopulation activity. Moreover, EPCR expression is associated with the stem cell activity of bone marrow cell populations isolated using conventional markers, indicating the usefulness of EPCR as a single marker for the identification of mouse HSCs.
Subtype
Primary Antibodies
Target Antigen
EPCR (CD201)
Alternative Names
Activated protein C receptor, APC receptor, CCD41, CD201, endothelial protein C receptor, PROCR, protein C receptor
Reactive Species
Mouse
Conjugation
Biotin, FITC, PE, Unconjugated
Host Species
Rat
Cell Type
Endothelial Cells, Hematopoietic Stem and Progenitor Cells
Species
Mouse
Application
Cell Isolation, Flow Cytometry, Functional Assay, Immunohistochemistry, Western Blotting
Flow cytometry analysis of HEK-293 mEPCR-transfected cells (filled histogram) or non-transfected HEK-293 cells (negative control; dashed line histogram), labeled with Anti-Mouse EPCR Antibody, Clone RMEPCR1560, followed by Goat Anti-Mouse IgG (H+L) Antibody, Polyclonal, FITC (Catalog #60138FI). Labeling of HEK-293 mEPCR-transfected cells with a rat IgG2b, kappa isotype control antibody, followed by Goat Anti-Mouse IgG (H+L)
Antibody, Polyclonal, FITC is shown (solid line histogram).
Figure 2. Data for Biotin-Conjugated
Flow cytometry analysis of HEK-293 mEPCR-transfected cells (filled histogram) or non-transfected HEK-293 cells (negative control cells, dashed line histogram), labeled with Anti-Mouse EPCR Antibody, Clone RMEPCR1560, Biotin followed by streptavidin (SAV) APC. Labeling of HEK-293 mEPCR-transfected cells with a rat IgG2b, kappa isotype control antibody followed by SAV APC is shown (solid line histogram).
Figure 3. Data for FITC-Conjugated
Flow cytometry analysis of HEK-293 mEPCR-transfected cells (filled histogram) or non-transfected HEK-293 cells (negative control cells, dashed line histogram), labeled with Anti-Mouse EPCR Antibody, Clone RMEPCR1560 FITC. Labeling of HEK-293 mEPCR-transfected cells with a rat IgG2b, kappa FITC isotype control antibody is shown (solid line histogram).
Figure 4. Data for PE-Conjugated
Flow cytometry analysis of HEK-293 mEPCR-transfected cells (filled histogram) or non-transfected HEK-293 cells (negative control cells, dashed line histogram), labeled with Anti-Mouse EPCR Antibody, Clone RMEPCR1560, PE. Labeling of HEK-293 mEPCR-transfected cells with a rat IgG2b, kappa PE isotype control antibody is shown (solid line histogram).
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