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Compound E

Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein

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Compound E

Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein

Catalog #
(Select a product)
Notch pathway inhibitor; Inhibits Notch receptor and amyloid precursor protein
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Overview

Compound E is a potent, cell-permeable, selective inhibitor that blocks the cleavage of both gamma-secretase and the Notch intracellular domain with similar IC50 values, ranging from 0.24 to 0.37 nM (Beher et al.; Seiffert et al.).


DIFFERENTIATION
· Inhibits growth, differentiation, and motility of neuroblastoma cells (Ferrari-Toninelli et al.).
· Accelerates the differentiation of human embryonic stem cells into primitive neural stem cells (Li et al.).
Cell Type
Brain Tumor Stem Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Differentiation, Maintenance
Area of Interest
Neuroscience
CAS Number
209986-17-4
Chemical Formula
C₂₇H₂₄F₂N₄O₃
"
Purity
≥ 98%
Pathway
Notch
Target
γ-³§±ð³¦°ù±ð³Ù²¹²õ±ð

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Name
Catalog #
73952, 73954
Lot #
All
Language
English
Document Type
Product Name
Catalog #
73952, 73954
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (3)

Brochure
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Cancer Research

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