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Mouse Recombinant IL-1 alpha

Interleukin 1 alpha

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Mouse Recombinant IL-1 alpha

Interleukin 1 alpha

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Interleukin 1 alpha
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Overview

Interleukin 1 alpha (IL-1α) is a member of the IL-1 family and a dual-function cytokine. Both the unprocessed precursor and a processed IL-1α protein signal through IL-1 receptor type 1 (IL-1R1). Various cells, including keratinocytes, thymic epithelium, hepatocytes, endothelial cells, fibroblasts, and the epithelial cells of mucous membranes have high levels of intracellular IL-1α precursor, which is also expressed on the surface of monocytes and B lymphocytes (Netea et al.). IL-1α recruits infiltrating cells to a site of injury during necrosis and plays an important role during processes of sterile inflammation (Rider et al.; Cohen et al.). During hypoxia, IL-1α contributes to angiogenesis (Carmi et al.). IL-1α is produced by microglia-like cells after ischemic brain injury, which contributes to the inflammation (Luheshi et al.).
Subtype
Cytokines
Alternative Names
BAF, B-cell-activating factor, Epidermal cell-derived thymocyte-activating factor, ETAF, FAF, Fibroblast-activating factor, IL-1F1, LAF, LEM, Leukocyte endogenous mediator, Lymphocyte-activating factor, MCF, Mononuclear cell factor
Cell Type
Angiogenic Cells, B Cells, Endothelial Cells, Epithelial Cells, Macrophages, Monocytes, Neural Stem and Progenitor Cells
Species
Mouse
Area of Interest
Angiogenic Cell Research, Endothelial Cell Biology, Epithelial Cell Biology, Immunology
Molecular Weight
18.1 kDa
Purity
≥ 95%

Data Figures

(A) The biological activity of Mouse Recombinant IL-1 alpha was tested by its ability to promote the proliferation of D10.G4.1 cells. Cell proliferation was measured after 72 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the cytokine at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.00581 ng/mL. (B) 1 μg of Mouse Recombinant IL-1 alpha was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Name
Catalog #
78129.1, 78129.2
Lot #
All
Language
English
Document Type
Product Name
Catalog #
78129.1, 78129.2
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages

Resources and Publications

Educational Materials (8)

Brochure
Brochure
Human Immune Cytokines
Wallchart
Human Immune Cytokines
Identification of Colonies Derived from Human Hematopoietic Progenitors
Wallchart
Identification of Colonies Derived from Human Hematopoietic Progenitors
Frequencies of Human Cell Types in Blood-Related Sources
Wallchart
Frequencies of Human Cell Types in Blood-Related Sources
Cell Isolation Directly from Whole Blood without RBC Lysis or Centrifugation: EasySepâ„¢ Direct
1:44
Video
Cell Isolation Directly from Whole Blood without RBC Lysis or Centrifugation: EasySepâ„¢ Direct
New Tools for the Ex Vivo Expansion of Human Hematopoietic Stem and Progenitor Cells
1:06:52
Webinar
New Tools for the Ex Vivo Expansion of Human Hematopoietic Stem and Progenitor Cells
Hematopoietic Stem and Progenitor Cells (HSPCs): Isolation, Culture, and Assays
Mini Review
Hematopoietic Stem and Progenitor Cells (HSPCs): Isolation, Culture, and Assays

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Quality Statement:

ºÚÁÏ³Ô¹Ï TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

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