Organoids in Drug Discovery
Predictive methods are needed to increase the chance of success in your drug programs before clinical trials. Organoids are a beneficial tool in drug discovery and toxicity testing, aiding target discovery, validation, and pre-clinical testing. Organoid models provide a more physiologically relevant cellular composition and tissue structure than standard 2D models, with increased accuracy and higher throughput. Additionally, patient-derived organoids can be used to predict drug toxicity and efficacy, allowing you to make precise and confident decisions to advance your drug candidates.
Learn how organoids can help your drug-discovery workflow below.
Interview: The Role of Organoids and Organ-On-A-Chip Systems in Drug Discovery
Drs Bas Trietsch, Chief Technology Officer at MIMETAS, and Jenna Moccia, Director of Product Management at ϳԹ, discuss the challenges that lead pharma companies to adopt advanced in vitro models, such as organoids and organ-on-a-chip, and the benefits they see after incorporating these systems in their research.
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Dynamic Modeling in OrganoidsLearn more about organoid applications for studying human health -
Initiating Intestinal Organoid Differentiation from Single-Cell hPSCs Using STEMdiff™<meta property="og:title" content="Using Single-Cell hPSCs for Intestinal Organoid Differentiation"/> <meta property="og:description" content="Want more control over your PSC cell populations for downstream differentiation? Check out our new protocol to learn how to prepare single cells for the use in intestinal organoid differentiations."/> <meta property="og:image" content="https://cdn.stemcell.com/media/images/social/PR00084-Intestinal-Organoid-Diff.jpg"/> <meta name="twitter:title" content="Using Single-Cell hPSCs for Intestinal Organoid Differentiation"/> <meta name="twitter:description" content="Want more control over your PSC cell populations for downstream differentiation? Check out our new protocol to learn how to prepare single cells for the use in intestinal organoid differentiations."/> <meta name="twitter:card" content="summary_large_image"/> <meta name="twitter:site" content="@ϳԹTech"/> <meta name="twitter:image" content="https://cdn.stemcell.com/media/images/social/PR00084-Intestinal-Organoid-Diff.jpg"/> -
Building Three-Dimensional Human Brain OrganoidsOverview of brain organogenesis and the applications of brain organoids in studying the development and maturation of the nervous system -
Nature Research Round Table: The Promise of Organoid MedicineDr. Takanori Takebe discusses how organoids can be used to expand clinical applications of diseases and disorders. Dr. Takebe is an Assistant Professor at the Cincinnati Children’s Hospital Medical Center and Associate Professor at Yokohama City University. <br><br> This presentation was part of a Round Table series titled “Advances in Organoid Applications”, organized in partnership with Nature Research and held at the Springer Nature headquarters in London, UK in June 2019. There, global organoid experts gathered to discuss the current state of the technology. Core discussions centered around protocol standardization, translation into patient care, nomenclature, and understanding what questions a given organoid culture can and can’t answer.
