“Printing Human Tissues” Featuring Dr. Anthony Atala
On this episode of the Stem Cell Podcast, Dr. Anthony Atala from the Wake Forest Institute for Regenerative Medicine discusses tissue engineering, vascularization, and prioritizing safety when studying lab-grown organs.
Dr. Anthony Atala is the Founding Director of the Wake Forest Institute for Regenerative Medicine. His team developed the first lab-grown organ to be implanted into a human and he currently oversees a team of over 400 researchers who are working to develop cell therapies and engineer replacement organs and tissues. He talks about multiple approaches to vascularization and his team's success in NASA's Vascular Tissue Challenge. He also discusses patience and prioritizing safety when studying lab-grown organs, and what we can learn from organoids.
Dr. Anthony Atala is a legend in the fields of tissue engineering and regenerative medicine. He and his team at Wake Forest have been able to achieve the dream of many bioengineers — creating functional tissues ex vivo for clinical translation.
Dr. Arun Sharma, host
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This Episode's Stem Cell Roundup:
- – Researchers generated functional mouse oocytes from PSCs that could be fertilized and result in viable offspring.
- – An alternatively spliced isoform of the enzyme Dicer, called aviD, protects mammalian stem cells from RNA viruses through RNA interference.
- – Scientists generated engineered heart tissue systems with dynamic loading to model diseases such as arrhythmogenic cardiomyopathy.
- – Researchers used transcriptomics and iPSC-derived endothelial cells from pulmonary hypertension patients to identify a tyrosine kinase inhibitor that improved vascular function in a rat model.
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