Pulmonary Organoids
Recent advances in isolating epithelial progenitor cells and stromal cells, as well as defining niche factors important for lung development, have led to the establishment of an in vitro 3D lung culture system: pulmonary (lung) organoids.
Below is a collection of resources to support your pulmonary research.
Featured
Organoids: Experts Talk Standardization at Nature Research Round Table
Global organoid experts gathered in London, UK to discuss the current state of the technology, protocol standardization, translation into patient care, nomenclature, and understanding what questions a given organoid culture can and can't answer.
Read Now >Key Applications of Pulmonary Organoids
Lung Stem Cell Biology
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Barkauskas CE et al. (2013) J Clin Invest 123(7): 3025–36.
Frank DB et al. (2016) Cell Rep 17(9): 2312–25.
Gao X et al. (2015) J Cell Biol 211(3): 669–82.
Jain R et al. (2015) Nat Commun 6: 6727.
Hegab AE et al. (2015) Stem Cell Res 15(1): 109–21.
Rock JR et al. (2009) Proc Natl Acad Sci U S A 106(31): 12771–5.
Tadokoro T et al. (2014) Proc Natl Acad Sci U S A 111(35): E3641-9.
Tadokoro T et al. (2016) Development 143(5): 764–73.
Barkauskas CE et al. (2013) J Clin Invest 123(7): 3025–36.
Frank DB et al. (2016) Cell Rep 17(9): 2312–25.
Gao X et al. (2015) J Cell Biol 211(3): 669–82.
Jain R et al. (2015) Nat Commun 6: 6727.
Hegab AE et al. (2015) Stem Cell Res 15(1): 109–21.
Rock JR et al. (2009) Proc Natl Acad Sci U S A 106(31): 12771–5.
Tadokoro T et al. (2014) Proc Natl Acad Sci U S A 111(35): E3641-9.
Tadokoro T et al. (2016) Development 143(5): 764–73.
Pluripotent Stem Cell-Derived Lung Organoids
Dye BR et al. (2016) Elife 5 5: e19732.
Dye BR et al. (2015) Elife 4 4: e05098.
Gotoh S et al. (2014) Stem cell reports 3(3): 394–403.
Konishi S et al. (2016) Stem cell reports 6(1): 18–25.
Dye BR et al. (2015) Elife 4 4: e05098.
Gotoh S et al. (2014) Stem cell reports 3(3): 394–403.
Konishi S et al. (2016) Stem cell reports 6(1): 18–25.
Cancer Research and Disease Modeling
Arai D et al. (2015) J Pathol 235(4): 593–605.
Dai Y et al. (2016) Oncotarget. Epub ahead of print, DOI: 10.18632/oncotarget.13686.
Quantius J et al. (2016) PLoS Pathog 12(6): e1005544.
Sun L et al. (2016) Am J Cancer Res 6(10): 2277–88.
Dai Y et al. (2016) Oncotarget. Epub ahead of print, DOI: 10.18632/oncotarget.13686.
Quantius J et al. (2016) PLoS Pathog 12(6): e1005544.
Sun L et al. (2016) Am J Cancer Res 6(10): 2277–88.
Co-Culture, Extra-Cellular Matrix (ECM) and Scaffolds
Dye BR et al. (2016) Elife 5 5: e19732.
Lee J-H et al. (2014) Cell 156(3): 440–55.
Liang J et al. (2016) Nat Med 22(11): 1285–93.
Peng T et al. (2015) Nature 526(7574): 578–82.
Shen Y et al. (2015) Sci Rep 5: 9293.
Tan Q et al. (2017) Biomaterials 113: 118–32.
Lee J-H et al. (2014) Cell 156(3): 440–55.
Liang J et al. (2016) Nat Med 22(11): 1285–93.
Peng T et al. (2015) Nature 526(7574): 578–82.
Shen Y et al. (2015) Sci Rep 5: 9293.
Tan Q et al. (2017) Biomaterials 113: 118–32.
Lung Organoid Reviews
Choi J et al. (2016) Dev Biol 420(2): 278–86.
Dye BR et al. (2016) Curr Pathobiol Rep 4(2): 47–57.
Hogan BLM et al. (2014) Cell Stem Cell 15(2): 123–38.
Konar D et al. (2016) Biomed Eng Comput Biol 7(Suppl 1): 17–27.
Mou H et al. (2015) Pediatr Pulmonol (S40): S14-23.
Schilders KAA et al. (2016) Respir Res 17(1): 44.
Dye BR et al. (2016) Curr Pathobiol Rep 4(2): 47–57.
Hogan BLM et al. (2014) Cell Stem Cell 15(2): 123–38.
Konar D et al. (2016) Biomed Eng Comput Biol 7(Suppl 1): 17–27.
Mou H et al. (2015) Pediatr Pulmonol (S40): S14-23.
Schilders KAA et al. (2016) Respir Res 17(1): 44.
