Naïve and Ground-State Pluripotency
Human pluripotent stem cells (hPSCs) can be maintained along a spectrum of different pluripotent states. In vitro, different cell culture media with specific combinations of cytokines or small molecules have been shown to maintain cells in either a naïve or primed pluripotent state. Multiple research groups have recently identified different culture conditions capable of shifting and maintaining hPSCs toward the "ground" or "naïve" state and away from the traditional primed state of hPSCs.
Explore the resources below for information on the ground state hPSC research.
Human Naïve-Like Pluripotent Stem Cell Generation and Maintenance
Dr. Arwen Hunter, a scientist at ϳԹ, describes the application of RSeT™ medium to revert and maintain primed hPSCs to ground or naïve-like state. This video was filmed during the Innovation Showcase at ISSCR 2016 in San Francisco.
View Now >Key Applications of Naïve-Like Stem Cells
Vallot C et al. (2016) Cell Stem Cell 20(1):102-111< O'Brien CM et al. (2016) Stem Cells 35(3):626-640Liu X et al. (2017) Nat Methods 14 11 1055-1062
Ward E et al. (2017) Stem Cells Dev 26(15):1087-1089
Collier AJ et al. (2017) Cell Stem Cell 20(6):874-890
Varga E et al. (2017) Stem Cell Res 21:19-22
